{"id":266,"date":"2024-03-24T11:13:47","date_gmt":"2024-03-24T11:13:47","guid":{"rendered":"https:\/\/senescex.com\/?page_id=266"},"modified":"2026-03-04T10:33:08","modified_gmt":"2026-03-04T10:33:08","slug":"grupo-uam-sd","status":"publish","type":"page","link":"https:\/\/senescex.com\/index.php\/grupo-uam-sd\/","title":{"rendered":"GRUPO UAM-SD"},"content":{"rendered":"

GROUP UAM-SD<\/h1>\n
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\"\"Marta Magari\u00f1os<\/strong> has a PhD in Science from the Universidad Aut\u00f3noma de Madrid<\/strong>. The studies carried out during her doctoral thesis and the first post-doctoral years focused on the study of LIM-HD<\/strong> proteins in determining the early neuronal identity of Drosophila melanogaster. She has done several international research stays for approximately two years at the Institute of Biology III<\/strong> (Freiburg, Germany), the Neurobiotechnology<\/strong> Center (Columbus, USA), the Baylor College of Medicine (Houston, USA) and the Institute for Medical Radiation Science and Cell Research the University of W\u00fcrzburg, MSZ (W\u00fcrzburg, Germany).<\/p>\n

From 2005 to 2019 her research was focused on chicken and mouse models, studying the molecular and cellular bases that drive inner ear development and function within the group led by Dra. Isabel Varela-Nieto<\/strong> (Alberto Sols Institute of Biomedical Research (CSIC-UAM). She studied the factors (IGF-1, TGF-b2) and the signaling pathways (RAF-MEK-ERK, PI3K-AKT, TGFb\/SMAD) through which the different cellular actions are carried out. She has studied the specification of the acoustic-vestibular<\/strong> ganglion during early neurogenesis, the relationships between the survival and cell death pathways, autophagy<\/strong>, proliferation, and early cell differentiation.<\/p>\n

Marta Magari\u00f1os<\/strong> is currently an Associated Professor of Fisiolog\u00eda<\/strong> Animal in the Biology Department of the UAM<\/strong> where she is studying the role of physiological<\/strong> cell senescence during development. For this, the most pertinent models are used in each case, whether they are vertebrates (chicken embryos and mice) or invertebrates<\/strong> (Drosophila melanogaster). Currently<\/strong>, the group has two Doctoral<\/strong> Theses in progress (Pablo Palau Irisarri and F\u00e9lix-S\u00e1nchez Valverde<\/strong>) centered on the role of senescence during CHARGE<\/strong> syndrome and on cell senescence upon nervous system damage in Drosophila<\/strong> melanogaster.<\/p>\n<\/div>\n

PROJECTS (LAST 5 YEARS)<\/h1>\n
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    \n
  • T\u00edtulo: \u201cSenescencia celular en fisiolog\u00eda y enfermedad\u201d.
    Entidad financiadora: Comunidad de Madrid, BIOMEDICINA 2022.
    Referencia: P2022\/BMD-7393.
    Duraci\u00f3n: 2023\u20132027.
    Investigador Principal: Marta Magari\u00f1os.<\/li>\n
  • T\u00edtulo: \u201cAltered developmental senescence of semicircular canals as the basis of CHARGE syndrome vestibular defects\u201d.<\/strong>
    Entidad financiadora: CHARGE Syndrome Foundation, U.S.A.<\/strong>
    Duraci\u00f3n: 2020\u20132021.<\/strong>
    Investigadores Principales: Marta Magari\u00f1os y Manuel Collado.<\/strong><\/li>\n<\/ul>\n<\/div>\n
    \n
      \n
    • T\u00edtulo: \u201cPapel de la senescencia celular en la regeneraci\u00f3n de tejidos\u201d.
      Referencia: BIOUAM01-2020.
      Entidad financiadora: Departamento de Biolog\u00eda, Facultad de Ciencias, UAM.
      Duraci\u00f3n: 2020\u20132021.
      Investigador Principal: Marta Magari\u00f1os.<\/li>\n
    • T\u00edtulo: \u201cDesarrollo de nuevas terapias para la prevenci\u00f3n y tratamiento de la p\u00e9rdida auditiva basadas en la identificaci\u00f3n de par\u00e1metros gen\u00e9ticos, bioqu\u00edmicos y moleculares\u201d.<\/strong>
      Referencia: SAF2017-86107-R.<\/strong>
      Entidad financiadora: Ministerio de Econom\u00eda, Industria y Competitividad, Agencia Estatal de Investigaci\u00f3n y Fondo Europeo de Desarrollo Regional (FEDER).<\/strong>
      Duraci\u00f3n: 2018\u20132020.<\/strong>
      Investigadores Principales: Isabel Varela-Nieto y Marta Magari\u00f1os.<\/strong><\/li>\n<\/ul>\n<\/div>\n

      RELEVANT PUBLICATIONS<\/h1>\n
      \n
        \n
      • Dysfunction of programmed embryo senescence is linked to genetic developmental defects.<\/strong>
        de Lope C, Garc\u00eda-Lucena R, Magari\u00f1os M, Le\u00f3n Y, Casa-Rodr\u00edguez N, Contreras N, Escudero-Iriarte C, Varela-Nieto I, Maire P, Palmero I<\/strong>.
        Development. 2023 May 1;150(9):dev200903.
        DOI: 10.1242\/dev.200903.<\/li>\n
      • Ceramide kinase inhibition blocks IGF-1-mediated survival of otic neurosensory progenitors by impairing AKT phosphorylation.
        Le\u00f3n Y, Magari\u00f1os M, Varela-Nieto I.
        Front. Cell Dev. Biol. 9:678760 (2021).
        DOI: 10.3389\/fcell.2021.678760.<\/li>\n
      • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).<\/strong>
        Klionsky DJ et al. <\/strong>Autophagy. 2021 Jan;17(1):1\u2013382.<\/strong><\/li>\n<\/ul>\n<\/div>\n
        \n
          \n
        • Otic neurogenesis is regulated by TGF\u03b22 in a senescence-independent manner.
          Magari\u00f1os M, Barajas R, Varela-Nieto I, Aburto MR.
          Front. Cell Neurosci. 2020.
          DOI: 10.3389\/fncel.2020.00217.<\/li>\n
        • Complementary and distinct roles of autophagy, apoptosis and senescence during early inner ear development.<\/strong>
          Varela-Nieto I, Palmero I, Magari\u00f1os M.<\/strong>
          Hearing Research. 2019 May;376:86\u201396.<\/strong>
          DOI: 10.1016\/j.heares.2019.01.014.<\/strong><\/li>\n<\/ul>\n<\/div>\n


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          GROUP UAM-SD Marta Magari\u00f1os has a PhD in Science from the Universidad Aut\u00f3noma de Madrid. The studies carried out during her doctoral thesis and the first post-doctoral years focused on the study of LIM-HD proteins in determining the early neuronal identity of Drosophila melanogaster. She has done several international research stays for approximately two years […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-266","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/senescex.com\/index.php\/wp-json\/wp\/v2\/pages\/266","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/senescex.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/senescex.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/senescex.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/senescex.com\/index.php\/wp-json\/wp\/v2\/comments?post=266"}],"version-history":[{"count":16,"href":"https:\/\/senescex.com\/index.php\/wp-json\/wp\/v2\/pages\/266\/revisions"}],"predecessor-version":[{"id":772,"href":"https:\/\/senescex.com\/index.php\/wp-json\/wp\/v2\/pages\/266\/revisions\/772"}],"wp:attachment":[{"href":"https:\/\/senescex.com\/index.php\/wp-json\/wp\/v2\/media?parent=266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}