GROUP UAM-SD

Marta Magariños has a PhD in Science from the Universidad Autónoma de Madrid. The studies carried out during her doctoral thesis and the first post-doctoral years focused on the study of LIM-HD proteins in determining the early neuronal identity of Drosophila melanogaster. She has done several international research stays for approximately two years at the Institute of Biology III (Freiburg, Germany), the Neurobiotechnology Center (Columbus, USA), the Baylor College of Medicine (Houston, USA) and the Institute for Medical Radiation Science and Cell Research the University of Würzburg, MSZ (Würzburg, Germany).

From 2005 to 2019 her research was focused on chicken and mouse models, studying the molecular and cellular bases that drive inner ear development and function within the group led by Dra. Isabel Varela-Nieto (Alberto Sols Institute of Biomedical Research (CSIC-UAM). She studied the factors (IGF-1, TGF-b2) and the signaling pathways (RAF-MEK-ERK, PI3K-AKT, TGFb/SMAD) through which the different cellular actions are carried out. She has studied the specification of the acoustic-vestibular ganglion during early neurogenesis, the relationships between the survival and cell death pathways, autophagy, proliferation, and early cell differentiation.

Marta Magariños is currently an Associated Professor of Fisiología Animal in the Biology Department of the UAM where she is studying the role of physiological cell senescence during development. For this, the most pertinent models are used in each case, whether they are vertebrates (chicken embryos and mice) or invertebrates (Drosophila melanogaster). Currently, the group has two Doctoral Theses in progress (Pablo Palau Irisarri and Félix-Sánchez Valverde) centered on the role of senescence during CHARGE syndrome and on cell senescence upon nervous system damage in Drosophila melanogaster.

PROJECTS (LAST 5 YEARS)

  • Título: “Senescencia celular en fisiología y enfermedad”.
    Entidad financiadora: Comunidad de Madrid, BIOMEDICINA 2022.
    Referencia: P2022/BMD-7393.
    Duración: 2023–2027.
    Investigador Principal: Marta Magariños.
  • Título: “Altered developmental senescence of semicircular canals as the basis of CHARGE syndrome vestibular defects”.
    Entidad financiadora: CHARGE Syndrome Foundation, U.S.A.
    Duración: 2020–2021.
    Investigadores Principales: Marta Magariños y Manuel Collado.
  • Título: “Papel de la senescencia celular en la regeneración de tejidos”.
    Referencia: BIOUAM01-2020.
    Entidad financiadora: Departamento de Biología, Facultad de Ciencias, UAM.
    Duración: 2020–2021.
    Investigador Principal: Marta Magariños.
  • Título: “Desarrollo de nuevas terapias para la prevención y tratamiento de la pérdida auditiva basadas en la identificación de parámetros genéticos, bioquímicos y moleculares”.
    Referencia: SAF2017-86107-R.
    Entidad financiadora: Ministerio de Economía, Industria y Competitividad, Agencia Estatal de Investigación y Fondo Europeo de Desarrollo Regional (FEDER).
    Duración: 2018–2020.
    Investigadores Principales: Isabel Varela-Nieto y Marta Magariños.

RELEVANT PUBLICATIONS

  • Dysfunction of programmed embryo senescence is linked to genetic developmental defects.
    de Lope C, García-Lucena R, Magariños M, León Y, Casa-Rodríguez N, Contreras N, Escudero-Iriarte C, Varela-Nieto I, Maire P, Palmero I.
    Development. 2023 May 1;150(9):dev200903.
    DOI: 10.1242/dev.200903.
  • Ceramide kinase inhibition blocks IGF-1-mediated survival of otic neurosensory progenitors by impairing AKT phosphorylation.
    León Y, Magariños M, Varela-Nieto I.
    Front. Cell Dev. Biol. 9:678760 (2021).
    DOI: 10.3389/fcell.2021.678760.
  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
    Klionsky DJ et al. Autophagy. 2021 Jan;17(1):1–382.
  • Otic neurogenesis is regulated by TGFβ2 in a senescence-independent manner.
    Magariños M, Barajas R, Varela-Nieto I, Aburto MR.
    Front. Cell Neurosci. 2020.
    DOI: 10.3389/fncel.2020.00217.
  • Complementary and distinct roles of autophagy, apoptosis and senescence during early inner ear development.
    Varela-Nieto I, Palmero I, Magariños M.
    Hearing Research. 2019 May;376:86–96.
    DOI: 10.1016/j.heares.2019.01.014.

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